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Рецензент: д.мед.н., проф. Л.М. Іванова
ДЗ «Луганський державний медичний університет»
ГЗ «Луганский государственный медицинский университет»
State Establishment "Lugansk State Medical University"
The aim of the research was studying of indexes of blood lipids spectrum for patients of young age with chronic uncalculary cholecystitis in combination with hypertensive disease. 130 patients with CUC in combination with HD of the II stage in the age from 18 to 45 years were under care. There were 51 men (39,3%) and 79 women (60,7%) among examined patients. Duration of comorbide pathology according to the data of medical documents was from 2 to 7 years on the average 4,2±0,5 years. Patients that were under care had CUC mainly in the phase of the moderate recrudescence; according to the data of anamnesis the amount of the previous recrudescences of CUC was 2-3 times in a year. 116 (89,3%) patients had gradual beginning of disease. According to the data of anamnesis progression of recrudescences patients connected with eating of rich, fried food and also with nervous overstrain. More frequent recrudescence of CUC for the persons of young age with united HD was observed 1-2 times in a year (in 46,3% cases) and the most rarely recrudescences had 12 (8,9%) patients one time in 2-3 years. According to the data of anamnesis and medical documentation hypertensive hyperkinetic variant of dyskinesia of gall bladder (GB) predominated for patients with duration of disease to 5 years, hypotonic hyperkinetic variant had patients with duration of disease from 5 to 10 years, hypotonic hypokinetic variant had persons with duration of disease more than 10 years. The state of lipid exchange in the blood serum was studied by the level of total cholesterol (TC), triglycerids (TG), high density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC),very low-density lipoprotein cholesterol (VLDLC). All indexes of lipid exchange for patients with comorbide pathology statistically differed from the norm. Young patients with CUC in combination with HD had the level of TC in limits from 2,8 mmol/l to 7,4 mmol/l. The mid-value of TC for the examined patients was 6,18±0,23 mmol/l (р<0,01), id est multipleness of increase was 1,5. While researching of TG for the patients of young age with CUC in combination with HD the index discrepancy was from 0,8 to 3,1 mmol/l. Thus the middle level of TG for the examined patients was 2,0±0,12 mmol/l, that was reliable discrepancy from the physiologic norm (р<0,05). The level of LDLC on the average was3,37±0,25 mmol/l, that reliably differed from the physiologic norm (2,56±0,16 mmol/l; р<0,05), and differences in the concentration of the marked index were in limits from 2,44 to 5,09 mmol/l. The most of (72 persons - 55,4%) examined patients had the concentration of LDLC, that did not exceed the bounds of physiologic norm - 2,71±0,11 mmol/l (р>0,05). 58 (44,6%) patients had the increase of content of LDLC and it made 4,06±0,57 mmol/l (variation from 3,4 mmol/l to 5,09 mmol/l). Discrepancy of concentration of VLDLC in blood of patients of the young age with CUC in combination with HD was from 0,34 to 1,52 mmol/l. Mid-values of the index were 0,81±0,08 mmol/l, that was in 1,2 times higher than the norm (0,68±0,05 mmol/l; р<0,05). From them 52 (40,0%) patients had substantial increase (more 1,3 mmol/l) of VLDLC concentration in blood. 68 (52,3%) patients had moderate increase of this index (from 0,9 mmol/l to 1,3 mmol/l). For other patients with CUC in combination with HD the concentration of VLDLC remained within the limits of physiologic norm, although on the top limit. The mid-value of HDLTC concentration was 1,18±0,09 mmol/l (р<0,05), that was a reliable difference from the content of HDLC for healthy donors. The individual analysis of this index showed that all examined patients with CUC in combination with HD had the level of HDLC that did not exceed the bounds of physiologic norm.
It was revealed statistically reliable positive correlation between the level of TG and VLDLC in patients’ blood (r= 0,499), between VLDLC and TC (r= 0,734).
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