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19.05.2014, 09:01 | |
Резюме УДК 616.24-002+616.36-036 ДЗ «Луганський державний медичний університет» ГЗ «Луганский государственный медицинский университет» 91045, кв. 50-летия Обороны Луганска, 1 г, Луганск, Украина State Establishment "Lugansk State Medical University" 91045,50 Rokyv Oborony Luganska Block, 1G, Lugansk,Ukraine pulmon@mail.ru The goal of research was investigation of character and evidence of changes of immunity cellular link for patients with the community-acquired pneumonia combined with hepatic steatosis. For the studying of features indexes of immunity cellular link for patients with CAP, that proceeded in combination with HS, by the technique of random sampling it was selected 44 patients from which there were 24 men (54,5%) and 20 women (45,5%) that made the Ist group in that proceeding of CAP of moderately severe was established for 28 patients (63,6%) and heavy one had 16 patients (36,4%). From the examined patients with CAP with absence of any chronic pathology of liver by the method of random sampling it was selected 41 patients, among which there were 22 men (53,7%) and 19 women (46,3%) that made the IInd group in that the proceding of CAP of moderately severe was established for 27 patients (65,9%) and heavy one had 14 patients (34,1%). Researches of all patients were made during the acuty of CAP while hospitalization with corresponding diagnosis to the specialized pulmonary department. Patients with CAP of both groups at the admission to in-patient department (acuity of pneumonia) had the reduction of relative amount of circulatory T- lymphocytes (CD3+). So in comparison with the referential norm for the patients of the Ist group abundance of CD3+-lymphocytes was belower than norm on the average in 1,5 times (Р<0,01), in the IInd group it was in 1,3 times (Р<0,05). While intergroup comparison the abundance of CD3+-lymphocytes for the patients of the Ist group was on the average in 1,2 times belower than analogical index in the IInd group (P<0,05). An absolute number of lymphocytes with phenotype CD3+ in the acuty of CAP for the patients of the Ist group was belower in regard to the norm on the average in 1,8 times (Р<0,001), in the IInd group it was belower in 1,4 times (Р<0,01). The comparative analysis of absolute number of CD3+-cells in investigated groups testified that more evidence changes were in the Ist group. So the patients of the Ist group had an absolute number of circulatory T-lymphocytes (CD3+) that was on the average in 1,3 times belower than in the IInd group (P<0,05). The abundance of CD4+-lymphocytes (T-helpers/inducing substances) in this period for the examined patients of the Ist group was decreasing on the average in 1,8 times (P<0,01), in the IInd group it was decreasing in 1,4 times (P<0,05). While intergroup comparison relative content of Т-helpers (CD4+) for the patients of the Ist group was on the average in 1,3 times belower than analogical index in the IInd group (P<0,05). The absolute number of lymphocytes with phenotype CD4+ in the acute of CAP for the patients of the Ist group was on the average in 2,1 times (Р<0,001) belower in regard to the norm; in the IInd group it was belower in 1,5 times (Р<0,01). Moreover, for the patients of the Ist group an absolute number of circulatory Т-helpers (CD4+) was belower on the average in 1,4 times than for the examined patients of the IInd group (P<0,01). The relative content of CD8+-lymphocytes (suppressor T cells/killers) in the acute of CAP for the most patients of the Ist and IInd groups remained within the limits of the norm. The absolute amount of CD8+-cells was decreased in 1,3 times (Р<0,05) among the examined patients of the Ist group, in that time as for the patients of the IInd group the level of CD8+-lymphocytes was in the lower limit of the norm. While application of gradation method it was revealed a reliable difference between the values of immunoregulatory index CD4/CD8 for the patients of the Ist and the IInd groups in the acute of CAP (before beginning of treatment). The relative and absolute amount of CD22+-lymphocytes (total population of В-cells) in the acute of CAP for the most patients of both groups were kept within the limits of the norm. While research of functional activity of Т-cells according to the results of LBR with PHA it was set that in the acute of CAP for the patients of the Ist group the value of this index was belower in regard to the referential norm in 1,7 times (Р<0,001), in the IInd group it was belower in 1,3 times (Р<0,01). The comparative analysis of LBR index for the examined patients testified that more evidence changes had patients of the Ist groups, whose index of LBR was on the average in 1,3 times belower than for the examined patients of the IInd group (P<0,05). In future we plan to study influence of comorbidity on the cytokine profile of blood. Література | |
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