Резюме
Євтушенко О.М. Роль провізора у моніторингу безпеки лікарських засобів.
В статті висвітлені питання безпечного споживання лікарських засобів та раціональної фармакотерапії, зокрема, необхідність урахування інформації про несприятливі випадки побічної реакції при застосуванні лікарських засобів у амбулаторних хворих та при самолікуванні. Запропоновано алгоритм виявлення та фіксації несприятливих випадків ПР з використанням можливостей роздрібної аптечної мережі.
Ключові слова: лікарські засоби, побічна реакція, безпека споживання, моніторинг, аптека.
Резюме
Евтушенко Е.Н. Роль провизора в мониторинге безопасности лекарственных средств.
В статье освещены вопросы безопасного потребления лекарственных средств и рациональной фармакотерапии, в частности, необходимости учета информации о неблагоприятных случаях побочной реакции при применении лекарственных средств у амбулаторных больных и при самолечении. Предложен алгоритм выявления и фиксации неблагоприятных случаев ПР с использованием возможностей розничной аптечной сети.
Ключевые слова: лекарственные средства, побочная реакция, безопасное потребление, мониторинг, аптека.
Summary
Yevtushenko O. The role of pharmacist in medicines safety monitoring.
The article highlights the safety use of medicines and rational drug therapy, in particular, the need to incorporate information about adverse reactions in the use of medicines for outpatients and self-medication. The algorithm for identifying and registration of adverse events with the use of the drugstores opportunities has been proposed.
Key words: medicines, side effects, safe consumption, monitoring, drugstore.

Рецензент: д.фарм.н., доц. Р.В. Сагайдак-Нікітюк

Національний фармацевтичний університет (Харків)

Национальный фармацевтический университет (Харьков)

National University of Pharmacy

evtyshenkolena@rambler.ru

Monitoring of the safety of medicines in their medical use is a major focus in the realization of the national pharmaceutical policy all over the world.

The level of development of the national monitoring system to the safety of medicines depends on the amount and quality of information about adverse reactions which coming from various sources.

The main tasks of monitoring is to collect, analyze and systematize of information about adverse reactions, dissemination of data on the pharmacological properties of medicines, their safety use, and research work on the development of methods and standards for determining risk and benefit during pharmacotherapy.

It is assumed that the received data on volume of pharmacotherapy, the number of adverse reactions and elimination of their consequences will reduce the costs of methods of covering or additional treatment, the acceptance of appropriate regulatory decisions, improvement the quality of pharmacotherapy.

The final purpose is optimization of financial costs of treatment and improvement the quality of medical and pharmaceutical care.
If self-treatment or outpatient treatment  the information about adverse reactions may be lost in the medical history or incorrectly recorded.

Also in the outpatient treatment a district doctor does not always have feedback from the patient and in case of adverse reaction a patient often stops taking medications without notice.

This means that many cases of adverse reactions simply not taken into account and, accordingly, there is a need to advance the existing system for the most complete data collection.

In connection with the above, the purpose of investigation was the development of approaches and recommendations to improve the data collection about adverse reaction with outpatients or in self.

The author notes that the presence of modern information technology in the drug stores easily allow to pharmacist / clinical pharmacist to collection and to consolidation of relevant information .

Special forms for to pharmacist / clinical pharmacist for identification adverse reactions, which has some differences from the established by Ukraine’s Ministry of Health special forms for reporting adverse reactions, were proposed. This allows to identify the medicine which provoked adverse reactions and to determine its form promptly, directly at the drugstore, even in the absence of information and resources that are at the doctor (medical card, medical history, test results, pharmacotherapy ...).

Information can be recorded as the electronic map of the patient (for a more rational pharmacotherapy) and come to the clinic databases.

 Graphs for adverse reaction manifestation in different body systems (gastrointestinal, nervous, etc.), for age and sex of respondents, for possible diagnosis, for patient’s pharmacotherapy are provided in this form.

Of course, the error of reliability degree is much increased, but due to mass character we can see the messages that would never have come to a specialist.
another option for data collection - electronic patient card , where a pharmacist has access only to specific sections relating to drug therapy, possible side effects, drug interactions is possible also.

An algorithm for detecting and recording adverse events together with prescription monitoring increase the degree of spontaneous reports to the pharmacovigilance’s centers, will contribute to a more complete and accurate information about the range of adverse reactions, their rate of development, the identification of rare, unexpected and serious reaction, the timely development of risk management strategy in pharmaceutical care and measures for the effective and safe use of medicines.

Література

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